DTU Studieprojekt - Gut health product discovery with microfluidics

Danmarks Tekniske Universitet (DTU)

Study project
Greater Copenhagen

Gut health product discovery with microfluidics

Udbyder
Vejleder
Sted
København og omegn
Project outline
Fermentable Oligo, Di, Mono-saccharides and Polyols are short chain carbohydrates that are good carbon sources for bacteria such as Lactic acid bacteria. Lactic acid bacteria are important for various applications within food for fermentation of milk into yoghurt, cheese etc., for fermentation of vegetables, fish and meat for conservation eg. dry sausages like salami. Also, for many years lactic acid bacteria have been used as food supplement for various health reason to balance the human and animal gut. Especially useful to treat diarrhea or more recently also to secure the health of small children from bacterial infections which under certain conditions in poor and malnourished children otherwise could lead to sepsis and in some of these cases death. [1].

  • In 2016, Novozymes together with Astra ran the Masseeksperimentet 2018, where 25000 Danish school students went out into nature to isolate new Lactobacillus strains, finding 3906 unique isolates of which 649 are unknown bacterial strains [2]. Now we would like to characterize the carbon source preferences of this large set of new microbial diversity. To make this characterization ultra-fast our microfluidics technology will be used. This lab-on-the-chip technology allows the targeted description of millions of microbes in just a few hours [3].
  • Technologies: Microfluidics, Lactobacillus cultivation, NGS, BioTyper

During the project the student will design growth media that allows optimal growth of Lactobacilli. The microbes are grown and selected with the microfluidics technology and further characterized with Biotyper and next generation sequencing (NGS).

References

  • [1]Panigrahi, Pinaki & Parida, Sailajanandan & C. Nanda, Nimai & Satpathy, Radhanath & Pradhan, Lingaraj & Chandel, Dinesh & Baccaglini, Lorena & Mohapatra, Arjit & S. Mohapatra, Subhranshu & R. Misra, Pravas & Chaudhry, Rama & H. Chen, Hegang & Johnson, Judith & Glenn Morris, J & Paneth, Nigel & Gewolb, Ira. (2017). A randomized synbiotic trial to prevent sepsis among infants in rural India. Nature. 548. 10.1038/nature23480.

[2] https://naturvidenskabsfestival.dk/masseeksperiment

[3] Lu, Heng, et al.

  • "High throughput single cell counting in droplet-based microfluidics." Scientific Reports 7.1 (2017): 1366.
I samarbejde med
Novozymes

Emneord

Tags
Kontakt
Virksomhed/organisation
DTU Fødevareinstituttet

Navn
Claus Heiner Bang-Berthelsen

Stilling
Seniorforsker

Mail
claban@food.dtu.dk

Vejleder-info
Kandidatuddannelsen i Bioteknologi
Vejleder
Claus Heiner Bang-Berthelsen

ECTS-point
25 - 30

Type
Kandidatspeciale

Kandidatuddannelsen i Kemisk og Biokemisk Teknologi
Vejleder
Claus Heiner Bang-Berthelsen

ECTS-point
25 - 30

Type
Kandidatspeciale


Open application date

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Study project
Greater Copenhagen
Chemistry, Biotech & Material Sciences
Education
Math, Physics & Nanotech
Natural Sciences
Production, Logistics & Transport
Technology
Veterinary & Food Sciences
Natural Sciences
Research & Development
Technology



Danmarks Tekniske Universitet (DTU) at a glance


Danmarks Tekniske Universitet (DTU)
Danmarks Tekniske Universitet (DTU)
DTU er et teknisk eliteuniversitet med international rækkevidde og standard. Vores mission er at udvikle og nyttiggøre naturvidenskab og teknisk videnskab til gavn for samfundet. 11.200 studerende uddanner sig her til fremtiden, og 6.000 medarbejdere har hver dag fokus på uddannelse, forskning, myndighedsrådgivning og innovation, som bidrager til øget vækst og velfærd.

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