DTU Studieprojekt - Systems genetics approaches in an internationally unique migraine study

Danmarks Tekniske Universitet (DTU)

Studieprojekt/speciale
Storkøbenhavn
Øresundsregionen

Systems genetics approaches in an internationally unique migraine study

Udbyder
Virksomhed / Organisation
Sted
København og omegn
The molecular genetics group at the Danish Headache Center, Rigshospitalet-Glostrup (mgDHC) is offering a unique master’s thesis projects in the analysis of RNA-Sequencing data of migraine patients.

Background:

Migraine is a heritable neurovascular headache disorder with recurrent headaches and it affects almost 20% of the population. The migraines are moderate to severe headache lasting 4 to 72 hours. Migraine patients are divided into two groups depending on whether the attack is associated with an aura, i.e. perceptional disturbances e.g. visual disturbance that is occurring prior to a migraine attack. The pathology of migraine is not completely understood, however 38 loci have been associated with increased risk of migraine. Only a small part of the migraine heritability is explained by these findings.

The migraine bus project:
We have an internationally unique cohort of 30 migraineurs that have been followed in- and outside of migraine attack. We collected blood samples at four time points that have been RNA-Sequenced and metabolomic profiling is as we speak performed at SSI. We furthermore have both genotype data and whole genome sequencing data on all migraineurs. We have a control sample of 20 healthy individuals, which are also RNA-Sequenced, whole genome sequenced, genotyped and metabolomic profiling is being performed. We want to discover genes, metabolites and pathways involved in migraine using several approaches, e.g.:

- Differential expression analysis

- Alternative splicing events

- Allele-specific eQTLs

- Differential network analysis

- Integration of genomics – metabolomics – transcriptomics

Qualifications:

You have a bioinformatics or life science background with flair for data analysis and scripting. You have experience with R and UNIX/Linux environment. Ideally, you also have experience with Python/ Perl or other scripting language but it is not a requirement. You are ambitious, positive, a team player and enjoy taking initiative with a high degree of commitment. Project length is 3 - 12 months (15 – 60 ECTS). If you are interested, please send a brief letter of motivation, resume and print of grades using the contact information below.

The project will be part of an ongoing project in the molecular genetics group at mgDHC (rigshospitalet Glostrup) and will therefore be carried out in close collaboration and under supervision of Lisette Kogelman, lead bioinformatics scientist.

Project start: ASAP

Contact info: Lisette Kogelman, E-mail: lisette.kogelman@regionh.dk

Forudsætninger
basic R-programming

Emneord

Kontakt
Virksomhed/organisation
Danish Headache Center, Rigshospital Glostrup

Navn
Lisette Kogelman

Stilling
Lead Bioinformatics Scientist

Mail
lisette.kogelman@regionh.dk

Telefon
38634358

Forslag til
Uddannelsesretning


Login for at se hele opslaget

Dette jobopslag er kun tilgængeligt for vores brugere. Log ind eller opret en profil - det er gratis og tager kun to minutter.

Log ind med sociale medier


Log ind med din karriereprofil

@


Glemt kode Ny bruger

Løbende ansøgningsfrist

Angiv venligst i din ansøgning, at du har ansøgt opslaget via Studerende Online

Studieprojekt/speciale
Storkøbenhavn
Øresundsregionen
Fødevarer & Veterinær
IT
Kemi, Biotek & Materialer
Matematik, Fysik & Nano
Medicinal & Sundhed
Naturvidenskab
Teknik & Teknologi
Forskning & Udvikling
Naturvidenskab
Teknik



Danmarks Tekniske Universitet (DTU) - hurtigt overblik


Danmarks Tekniske Universitet (DTU)
Danmarks Tekniske Universitet (DTU)
DTU er et teknisk eliteuniversitet med international rækkevidde og standard. Vores mission er at udvikle og nyttiggøre naturvidenskab og teknisk videnskab til gavn for samfundet. 11.200 studerende uddanner sig her til fremtiden, og 6.000 medarbejdere har hver dag fokus på uddannelse, forskning, myndighedsrådgivning og innovation, som bidrager til øget vækst og velfærd.

Placering
Anker Engelunds Vej 1
2800 Kgs. Lyngby
Logo: Danmarks Tekniske Universitet (DTU)
Efterspørgsel efter nye talenter

Hvilke jobtyper og arbejdsområder udbyder vi normalt og hvor mange nye talenter søger vi efter?


Nyeste tweets
Henter tweets...
Facebook feed

Henter facebook feed...

LinkedIn

Følg vores aktiviteter på LinkedIn.


Webside

Få mere info omkring vores virksomhed på vores egne websider:

www.dtu.dk


Danmarks Tekniske Universitet (DTU) i Google

Er der andre informationer om os, som du burde vide? Se, hvad en Google-søgning siger.



https://studerendeonline.dk/job/1273453/
Vi bruger cookies til statistik, sociale medier og brugeroplevelse. Ved at bruge sitet accepterer du vores privatlivspolitik. (luk)
HPT