PhD fellow to the project ‘Deciphering the link between adhesion and pluripotency’ at NNF Center for Stem Cell Biology (DanStem)

Københavns Universitet (KU)

Fuldtidsjob
Ph.d. & forskning
Storkøbenhavn
Øresundsregionen

NNF Center for Stem Cell Biology (DanStem - http://danstem.ku.dk) at Faculty of Health & Medical Sciences, University of Copenhagen, seeks a PhD fellow with a preliminary position as Research assistant.

Job description
Embryonic Stem Cells (ESCs) are genetically normal, immortal cell lines with the capacity to become any cell type in the future organism. This project will explore the role of cell-cell adhesion supporting a pluripotent state, both in vivo and in vitro. We recently found that the evolutionarily conserved gene regulatory network (GRN) downstream of one of the central pluripotency regulators, Oct. 4, was primarily concerned with regulating cell-cell adhesion (Livigni et al Curr Biol. 2013).
We would now like to link this network to the two mechanical properties of cells in tissues, mainly cortical tension and cell-cell adhesion in vivo. We seek to understand how the pluripotency network regulates cell-cell interaction, both at a transcriptional and post-transcriptional level and how mechanical forces retrospectively feed forward into genetic programs to govern both pluripotency and the entrance into differentiation. A large component of this work will be computational and will use NGS technologies to understand the link between adhesion and dynamic gene regulatory networks.

Qualifications

  • Master's degree in biology, biochemistry, medicine or human biology, or similar, and a general understanding of developmental biology, stem cell biology and particularly bioinformatics.
  • Strong motivation and very good scientific skills are essential.
  • Publications and practical experience are an advantage.
  • Good communication skills, oral and written.

Terms of salary, work, and employment
The position is full time as PhD fellow for 3 years following a period of up to 1 year as Research assistant (also full time). During the period as Research assistant, the candidate is expected to write and submit an application with regard to PhD enrolment.

Start: 1 April 2019 or upon agreement.

The employment as a PhD student is conditioned upon a positive assessment of the candidate's research performance and enrolment in the Graduate School at the Faculty of Health and Medical Sciences. The PhD study must be completed in accordance with the ministerial orders from the Ministry of Education on the PhD degree and the University's rules on achieving the degree.

Place of work is DanStem, University of Copenhagen, Blegdamsvej 3B, Copenhagen.

Terms of employment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

Questions
Please contact Professor Joshua Brickman by e-mail: joshua.brickman@sund.ku.dk or Jakub Sedzinski at; jakub.sedzinski@sund.ku.dk.

The application must include

    • Cover Letter, detailing your motivation and background for applying for the specific PhD project.
    • CV.
    • Diploma and transcripts of records (BSc and MSc).
    • Other information for consideration, e.g. list of publications (if any).
    • Full contact details of 1-3 professional referees.
    Your application, in English, must be submitted electronically by clicking ‘APPLY NOW’ below.

    Application deadline: 27 February 2019.

    Only applications received in time and consisting of the above listed documents will be considered.

    The application will be assessed according to the Ministerial Order no. 284 of 25 April 2008 on the Appointment of Academic Staff at Universities.

    The University of Copenhagen welcomes applications from all qualified candidates regardless of personal background.

    Københavns Universitet giver sine knap 10.000 medarbejdere muligheder for at udnytte deres talent fuldt ud i et ambitiøst, uformelt miljø. Vi sikrer traditionsrige og moderne rammer om uddannelser og fri forskning på højt internationalt niveau. Vi søger svar og løsninger på fælles problemer og gør ny viden tilgængelig og nyttig for andre.

    Kontakt
    Joshua Mark Brickman
    E-mail: joshua.brickman@sund.ku.dk

    Kontakt
    Jakub Sedzinski
    E-mail: jakub.sedzinski@sund.ku.dk

    Info
    Ansøgningsfrist: 27-02-2019

    Ansættelsesdato: 01-04-2019

    Arbejdstid: Fuldtid

    Afdeling/Sted: NNF Center for Stem Cell Biology (DanStem)


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