PhD student position in Precision Diagnostics in Cardiomyopathies

Region Hovedstaden

Ph.d. & forskning
Storkøbenhavn

A PhD position is available in the Unit for Inherited Cardiac Diseases at the Heart Center, Rigshospitalet, in close collaboration with academic partners at the University of Copenhagen.

The Unit for Inherited Cardiac Diseases was established in 2006 by Professor, Dr.med., Chief Physician Henning Bundgaard. The clinic performs research in and medical evaluation and diagnostic work-up of patients and relatives of patients with likely genetic/inherited cardiac disorders. Approximately 3,200 families are followed at the clinic and diseases vary from familial hypercholesterolemia to electrophysiological disorders to severe forms of cardiomyopathy.

The project
The overall aim of the project is to perform deep phenotyping of patients with cardiomyopathies, paving the way for precision medicine in cardiology. Deep phenotyping is carried out through translational research utilizing advanced molecular testing on tissue-samples, advanced cardiac imaging and investigative studies exploring the physiology of cardiac disease.

Furthermore, the unit has a history of performing clinical randomized trials and quality control trials utilizing data from large-scale registries and electronic health records which the successful candidate could become involved in.

The proposed PhD program will involve projects where patients with certain subtypes of cardiomyopathies are included in studies investigating:

  • Molecular disease mechanisms from myocardial biopsies.
  • Cardiac function through invasive and imaging studies (cardiac MRI and nuclear imaging studies).
  • Disease trajectories in cardiomyopathies as assessed from integrated large-scale data-sets.
  • Participation in clinical trials.

We offer
The successful candidate will be a part of a dynamic research team consisting of senior and junior cardiologists, basic researchers, other PhD students, medical students and data scientists. The team facilitates and participates in clinical studies, basic research studies and studies utilizing clinical and para-clinical data from large-scale registries.

As such, the candidate will have an opportunity to participate in studies carried out in a range of different settings and shape/influence particular research questions or modes of investigation in the project under the guidance of the associated supervisors.

The applicant will take active part in research seminars, conferences and workshops organized or attended by members of the research group.

Responsibilities and tasks
The PhD student will be responsible for identification and inclusion of appropriate patients in advanced molecular studies. Furthermore, the successful applicant will be responsible for the logistics and actively participate in invasive and imaging studies.

Qualifications
The successful candidate (MD) will have qualifications, experience and/or strong interest within one or several of the following areas:

  • Clinical experience and/or research
  • Research related to healthcare data from registries and electronic patient records
  • Research related to bioinformatics and systems biology at the molecular level
  • Have a genuine interest in genetic/molecular mechanisms underlying disease
  • Competences in statistics
  • Be independent and ambitious
  • Possess good interpersonal skills
  • Have great organizational capabilities.

Formal requirements
The research group is highly multidisciplinary and collaborates with many other research groups nationally and internationally. Strong networking and team player skills are therefore preferred. As the candidate may run several projects in parallel, strong organizational skills and the ability to keep an overview are important.

To be accepted for the position, it is a condition that you have a degree as – or considered to be equivalent to - a Danish Medical Doctor and have an authorization to work as a Danish Medical Doctor. You must also be proficient in Danish.

It is a prerequisite that the PhD candidate is enrolled as a PhD student at the Faculty of Health and Medical Sciences according to the rules stipulated in the Ministerial order on the PhD program at the universities (PhD order) from the Ministry of Science, Innovation, and Higher Education and the guidelines for the PhD program at the Faculty of Health and Medical Sciences.

Terms of salary and employment
The salary and appointment terms will be as a clinical assistant according to the Agreement for Junior Doctors as set out in Regionernes Lønnings- og Takstnævn. The candidate will be employed at the Heart Center, Rigshospitalet.

Supervisor/start date
The primary supervisor will be Professor, Chief physician Henning Bundgaard.

Proposed start date: As soon as possible.

Application
The application must be in English and include the following documents/attachment:

1. Motivated letter of application

2. Curriculum vitae

3. A certified/signed copy of MD certificate

4. A complete list of publications and conference presentations

The application should be submitted electronically. Please be aware that we only accept applications sent through the link.

Questions
For further details please contact Professor and Chief Physician Henning Bundgaard e-mail: henning.bundgaard@regionh.dk or Medical doctor/PhD-student Christoffer Vissing, e-mail: christoffer.rasmus.vissing@regionh.dk.

Deadline for application: 22 February 2019

Assessment of the applicants will be made by an assessment committee. Final assessment will be on the basis of an interview with an appointed committee.

All qualified candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.


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Ph.d. & forskning
Storkøbenhavn
Medicinal & Sundhed
Naturvidenskab
Forskning & Udvikling
Medicinal & Sundhed
Naturvidenskab
Socialvæsen
Undervisning



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