AU Studieprojekt: Neurodegeneration and inflammation

Aarhus Universitet (AU)

Studieprojekt/speciale
Udlandet (øvrige)
Østjylland (Aarhus)

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VirologToivoe gChriimstemnseun nologi tchr@biomed.au.dk Dept. Of Biomedicine – EAST Bartholins Allé 6 PhD students: Mikkel Carstensen Gjelstrup, MSc, Dorte T Hansen, MSc, Gro Helen Dale, MD, Viktoria Papp, MD Technician: Eva L Petersen Background The cause of the immune-mediated, neurological disease multiple sclerosis (MS) remains unknown. We focus on the MS-specific complex interplay of essential immunological pathways and the potential involvement of viruses in determining disease activity and progression in MS. We also have a specific interest in neuromyelitis optica spectrum disorders (NMOSD) and the anti-AQP4-response. We are very interested in human endogenous retroviruses (HERVs): Flow cytometric analysis of surface expression of HERV-H Env and HERV-W Env TM and SU epitopes on cells from MS long-term lymphoblastoid cell cultures. Brudek et al. 2009 and in the inflammatory response is patients with MS: … Expression of CD14 and CD16 on PBMCs from a healthy control (left) and a patient with RRMS (right). Activation status of monocytes in the peripheral blood is reflected by their expression of CD14 and CD16. Patients with CIS and RRMS have a higher proportion of activated monocytes (CD14-,CD16++) indicating an ongoing inflammatory condition. (Gjelstrup et al. 2018) Currently, all investigations are performed on primary samples from patients and controls. Our main goal is to gain sufficient insight into the cause and the pathogenesis of the diseases to create the basis for novel treatments. Projects and techniques Close collaborators: Chief Physician (neurology)Thor Petersen, DrMedSci, Head of MS Clinic, Department of Neurology, AUH, and Intern, (neurology) Morten Stilund, PhD, MS clinic, RHWJ: Clinical work, diagnostic work-ups, epidemiology. Professor Holger Jon Møller, Clinical Biochemistry, AUH: biomarkers. Professor Christian Muchardt, PhD, Dept. of Developmental and Stem Cell Biology, Institut Pasteur, Paris, France: epigenetic analysis, next-generation sequencing. Project elements: Inflammation and biomarkers in MS: Cell culture, flow cytometry (incl. ImageStream), fluorescence-activated cell sorting, RT-qPCR for a detailed characterization of monocyte and B cell populations in peripheral blood and CSF. ELISAs (or variations thereof) for biomarkers for inflammation and axonal degeneration. NMOSD and the anti-AQP4-response: Cell culture, flow cytometry, ELISAs/TRIFMAs, cell-based assays (CBA). HERVs in MS: Cell culture, PCR, cloning, analysis of expression, confocal microscopy, flow cytometry, cell based functional assays, ELISAs/TRIFMAs MS epigenetics: Cell culture, RNA and DNA specific methods including chromatin immunoprecipitation, ChIP-seq, RT- qPCR, high depth RNA sequencing. Use and interpretation of next-generation sequencing data. Recent publications: Christensen T & Muchardt C. The epigenetics of multiple sclerosis. in Chromatin Signaling and Neurological Disorders 2019 (Olivier Binda, ed), Translational epigenetics series. Elsevier, Chapter 05: 97-118. in press Gjelstrup MC et al. Subsets of activated monocytes and markers of inflammation in incipient and progressed multiple sclerosis. Journal of Immunology and Cell Biology 2018; 96:160-174 Hansen DT et al. Retroviral envelope proteins: Involvement in neuropathogenesis J Neurol Sci 2017, 380: 151-163


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Studieprojekt/speciale
Udlandet (øvrige)
Østjylland (Aarhus)
Fødevarer & Veterinær
Kemi, Biotek & Materialer
Matematik, Fysik & Nano
Medicinal & Sundhed
Naturvidenskab
Forskning & Udvikling
Medicinal & Sundhed
Naturvidenskab



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Aarhus Universitet (AU)
Aarhus Universitet (AU)
Aarhus Universitet blev grundlagt i 1928 og er i dag i den absolutte verdenselite på flere forskningsfelter. Aarhus Universitet (AU) er blandt verdens 10 bedste universiteter grundlagt inden for de seneste 100 år og har en lang tradition for partnerskaber med nogle af verdens bedste forskningsinstitutioner og universitetsnetværk.

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