DTU Studieprojekt - Three-dimensional (3D) printing of cardiac patches

Danmarks Tekniske Universitet (DTU)

Virksom - a-kasse og faglig organisation for selvstændige

Three-dimensional (3D) printing of cardiac patches

Udbyder
Vejleder
Sted
København og omegn
Cardiac patches are a new class of promising therapeutic approaches whichoffer a potential treatment for several heart diseases. What’s more, they provide means toward real-time monitoring of the well-being of the heart, when combined with state-of-the-art bioelectronics platforms. These biomaterial-based temporary scaffolds support cells and promote their maturation toward functional tissues. The effective organization of cells into a functional cardiac tissue, however, requires a 3D native-like microenvironment which mimics the physiological and mechanical properties of the natural extracellular matrix (ECM) in the heart. Despite the widespread use of electroconductive biomaterials to increase the physiological relevance of these patches, there are still several hurdles down the path to be tackled in terms of mechanical properties and durability. Along the same vein, the facile control of mechanical properties is essential in biointegrated electronics to minimize the perturbation of inherent motion in biological system, namely the heart. In this project, we aim to develop a hybrid self-adaptive epicardial patch (composed of an embedded sensor within a conductive hydrogel) to dynamically monitor the pulsing cardiomyocytes and further apply it as a cardiac patch. Specifically we plan to use 3D printing for the manufacturing of a native-like cardiac patch in a patient specific manner; and to generate a heart model to test it. In this setup, we plan to actuate the 3D printed heart model to recapitulate the biomechanical behavior of the human heart. Likewise the plan is to induce a defect on the model and employ the developed cardiac path hereon to monitor both the beating of the heart and how it heals.

Emneord

Bioteknologi og biokemi
Konstruktion og mekanik
Elektroteknologi
Energi
Fysik
Informationsteknologi
Kemi
Matematik
Materialer
Medicin og medicoteknik
Miljø og forurening
Produktion og ledelse
Bakterier og mikroorganismer
Biologiske systemer
Celler
Enzymer og proteiner
Fermentering
Gener og genomer
Syntetisk biologi
Vira
Forbrændingsmotorer
Maskinkonstruktion
Antenner
Elektromagnetisme
Elektronik
Elteknik
Lyd
Mikrobølgeteknologi
Robotteknik og automation
Elforsyning
Energieffektivisering
Energilagring
Energiproduktion
Energisystemer
Sundhedsfremmende stoffer
Klimaændringer
Billedanalyse
Dataanalyse
Hardware og komponenter
It-systemer
Software og programmering
Telekommunikation
Teknisk kemi
Matematisk modellering
Fysiologisk modellering
Høreapparater
Hospitalsindretning
Kunstige organer
Medicinske apparater og systemer
Nanomedicin
Radioaktive lægemidler og isotoper
Sundhed og sygdomme
Klimatilpasning
Miljøkemi
Entreprenørskab
Innovation og produktudvikling
Livscyklusanalyse
Operationsanalyse
Rumteknologi og instrumenter
Satellitter

Kontakt
Virksomhed/organisation
DTU Sundhedsteknologi

Navn
Alireza Dolatshahi-Pirouz

Stilling
Gruppeleder, Lektor

Mail
aldo@dtu.dk

Vejleder-info
Bachelor i Kunstig Intelligens og Data
Vejleder
Alireza Dolatshahi-Pirouz