DTU Studieprojekt - Investigating the molecular mechanisms underlying cardiac fibrosis

Investigating the molecular mechanisms underlying cardiac fibrosis

Udbyder
Vejleder
Sted
København og omegn
In the vast majority of heart diseases, fibrosis is an indispensable part of the pathophysiological disease progression. For instance, development and progression of fibrosis in the atria is a hallmark of the structural remodeling considered a main substrate for atrial fibrillation.

We hypothesize that the fibrotic processes in atrial fibrillation are orchestrated by intracellular signaling mechanisms in fibroblasts in the atria, that ultimately lead to a reprogramming of the fibroblasts to become activated, proliferate and cause fibrosis.

In this project we will study the signaling mechanisms underlying the activation of fibroblasts. We will measure protein expression levels in cardiac fibroblasts and study how these are regulated upon activation.

Protein expression will be analyzed using cutting-edge mass spectrometry technology. In collaboration with other members of our group, you will learn how to isolate and manipulate cardiac fibroblasts and to perform proteomics experiments.

The Lundby Group is an interdisciplinary research group investigating cardiac (patho)physiology using proteomics approaches. We are particularly interested in pinpointing changes in protein expression that lead to cardiac disease. We work in close collaboration with clinicians at Rigshospitalet allowing us to study material directly from patients. Our group consists of an international mix of backgrounds in biotechnology, biochemistry and bioinformatics – resulting in a dynamic and inspiring work environment!

Contact information:
Professor Alicia Lundby. Email: alicia.lundby@sund.ku.dk

Web: lundbylab.com

Allowed no of students per report: 1

I samarbejde med
Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen.

Emneord

• Bioteknologi og biokemi
• Medicin og medicoteknik
• Billedanalyse
• Fysiologisk modellering
• Høreapparater
• Hospitalsindretning
• Kunstige organer
• Medicinske apparater og systemer
• Nanomedicin
• Radioaktive lægemidler og isotoper
• Sundhed og sygdomme

• BiomedicalEngineering
• DTUhealthtech

Navn
Nina Kjærgaard Hendel

Stilling
Specialkonsulent

Mail
ninak@dtu.dk

Vejleder-info
Bachelor i Medicin og Teknologi
Vejleder
Nina Kjærgaard Hendel

Type
Bachelorprojekt, Kandidatspeciale

Bachelor i Kvantitativ Biologi og Sygdomsmodellering
Vejleder
Nina Kjærgaard Hendel

Type
Bachelorprojekt, Kandidatspeciale

Kandidatuddannelsen i Kvantitativ Biologi og Sygdomsmodellering
Vejleder
Nina Kjærgaard Hendel

Type
Bachelorprojekt, Kandidatspeciale

Kandidatuddannelsen i Medicin og Teknologi
Vejleder
Nina Kjærgaard Hendel

Type
Bachelorprojekt, Kandidatspeciale