DTU Studieprojekt - Evaluating dosimetric consequences of anatomical changes in radiotherapy

Evaluating dosimetric consequences of anatomical changes in radiotherapy

Udbyder
Vejleder
Sted
København og omegn
As the first clinic in the world we have implemented ETHOS, a new commercial solution for AI-driven CBCT-based daily online adaptive radiotherapy (oART).

The system applies structure-guided deformation of targets and organs at risk, from original definition on a reference CT to the high quality CBCT, based on initial AI-driven auto-segmentation of so-called influencer organs. Automated treatment planning and calculation-based QA then enables the choice of a re-optimized plan on the anatomy of the day. Ethos furthermore provide the possibility to evaluate/monitor the absorbed dose delivered to the patient per fraction, also for patients treated without online adaptation.

This is something that previously hasn’t been available in the clinical routine, where only changes in anatomy (and not dose) were evaluated. At Herlev, we now have >260 patients and >4000 fractions available in the system.

The aim with this project is to build a software infrastructure (package) to be able to evaluate changes in delivered dose compared to reference dose. Evaluation will be based on the data available in our clinical system and the purpose is to evaluate the data in a broad scale.

These data can be analyzed to identify underdosage/overdosage in target/risk organs and identify its origin i.e. dosimetric consequences of anatomical changes and its random or systematic pattern. Ultimately, the developed software infrastructure will demonstrate the value of an adaptive decision support system based on the data that has always been available but never used.

The ETHOS monitoring system uses deformable registration between CBCT and CT to generate the so-called synthetic CT (sCT) used for dose calculation. The drawback with sCT is that it doesn’t handle changes in density correctly e.g. if a gas-pocket with low HU number is present at the CT this area will have low HU at the sCT even though the gas is no longer present. An additional aim to this project could be to further investigate the uncertainties e.g. improving the sCT by introducing CBCT-guided density corrections and/or compare calculations on sCT with calculation on the CBCT.

Contact information:

Patrik Sibolt, Medical Physicist, PhD. Phone: +45 3868 6766. e-mail: patrik.sibolt@regionh.dk

David Sjöström, Deputy Chief Physicist. e-mail: david.sjostrom@regionh.dk

Claus Behrens, Lead Senior Scientist, Medical Physicist, PhD. e-mail: claus.behrens@regionh.dk

Jens Edmund, Medical Physicist, PhD. e-mail: jens.edmund@regionh.dk

Allowed no of students per report: 1-2

I samarbejde med
Department of Oncology (Radiotherapy Research Unit), Herlev & Gentofte Hospital, Herlev

Forudsætninger
Programming

Emneord

• Bioteknologi og biokemi
• Medicin og medicoteknik
• Billedanalyse
• Fysiologisk modellering
• Høreapparater
• Hospitalsindretning
• Kunstige organer
• Medicinske apparater og systemer
• Nanomedicin
• Radioaktive lægemidler og isotoper
• Sundhed og sygdomme

• BiomedicalEngineering
• DTUhealthtech

Navn
Kaj-Åge Henneberg

Stilling
Lektor

Mail
khen@dtu.dk

Vejleder-info
Bachelor i Medicin og Teknologi
Vejleder
Nina Kjærgaard Hendel

Type
Bachelorprojekt, Kandidatspeciale

Kandidatuddannelsen i Medicin og Teknologi
Vejleder
Nina Kjærgaard Hendel

Type
Bachelorprojekt, Kandidatspeciale