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Postdoc in infection biology, immunology and metabolomics

Aarhus Universitet (AU)



The Department of Biomedicine at Faculty of Health at Aarhus University invites applications for a position as Postdoc in the field of infection biology and immunology combined with metabolomics as per 1 May 2021 or as soon as possible thereafter. The position is a 3 year full-time position.

We offer a vibrant international research environment where English is the preferred language in the laboratory, at meetings and at seminars. The Department employs some 450 people and covers a range of research areas within Biomedicine. We contribute to the Bachelor’s degree programs in medicine, molecular medicine, odontology and the Master’s degree programs in biomedical engineering and medical chemistry. Our infrastructure is well developed with modern laboratories, core and animal facilities. You will work in the brand new ‘Skou Building’ located at the heart of the university campus, as well as at Dept of Forensic Medicine, located at Aarhus University Hospital Skejby. You can read more about the department here and about the faculty here. About the research project
Virus infections lead to immune activation, modulation of cellular activities, and alteration of metabolism. This leads to destruction of tissues and alteration of homeostatic activities, and hence disease development. Therefore, understanding of the mechanisms that govern alterations in metabolism and deciphering of the impact, will advance the understanding of viral disease mechanisms.

To address these questions, we will map the metabolic alterations that occur in virus-infected organs, and experimentally test key observations for functional impact.
For this purpose, we will use mouse models for virus infections (e.g. herpesvirus infections in the brain, and SARS-CoV2 infection in the lungs) and combine this with untargeted LC-MS based metabolomics analysis (LC-QTOF-MS and LC-MS/MS) , advanced complex data analysis tools, and in vitro model systems. This will allow us to both identify and explore metabolic alterations in virus-infected organs. The project is part of a larger program of mapping cellular transcription, activation stages, and metabolic impact with high temporal and spatial resolution, and to include machine leaning tools to uncover complex patterns in viral diseases. Your job responsibilities
As Postdoc in infection biology and immunology combined with metabolomics your position is primarily research-based but may also involve teaching assignments. You will contribute to the development of the department through research of high international quality. In your daily work, you will work closely with colleagues on your project, where you will receive supervision and guidance. The work related to the project will take place at both Department of Biomedicine (infection biology and immunology, prof. Søren Riis Paludan and assoc prof. Line Reinert) and Department of Forensic Medicine (metabolomics, prof. Mogens Johannsen), and the successful candidate will be integrated into both departments. Your main tasks will consist of: Independent research of high international quality, including publication.

You will report to Professor Søren Riis Paludan tel.: (+45) 28992066. Your competences
You have academic qualifications at the PhD level, preferably within one or more of the following areas immunology, biochemistry or cell biology, and with strong interest in metabolism. Applicants with previous documented experience with untargeted metabolomics and analysis of complex biological data sets will be preferred. This includes LC-QTOF-MS and LC-MS/MS based metabolomics analysis, metabolic pathway analysis and to lesser extend animal models, and in vitro cell culture systems. You should have solid analytical thinking, creativity, and a visible publication record. We offer a dynamic, ambitious, and productive environment for a young scientist, and a good platform for a future career in frontline research. Recent publications from the project group:

    • Zhang BC, et al. STEEP mediates STING ER exit and activation of signaling. Nature Immunology. 2020. 21:868-879.
    • Reinert et al. Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production. Journal of Clinical Investigation. 2021. 131(1):e136824:
    • Kold-Christensen R, Johannsen M. Methylglyoxal Metabolism and Aging-Related Disease: Moving from Correlation toward Causation. Trends Endocrinol Metab. 2020. 31:81-92.
    As a person, you are ambitious, take ownership and possess good communication and interpersonal skills. We expect you to be fluent in oral and written English. In order to be assessed as qualified for a Postdoc position, you must meet these academic criteria.

    Shortlisting will be used. Questions about the position
    If you have any questions about the position, please contact Professor Søren Riis Paludan tel.: (+45) 28992066; email: srp@biomed.au.dk, or professor Mogens Johannsen email: mj@forens.au.dk.

    We expect to conduct interviews the third week of March.
    Terms of employment

    • Appointment as a postdoc requires academic qualifications at PhD level.
    • Further information on the appointment procedure can be found in the Ministerial Order on the Appointment of Academic Staff at Universities.
    • The appointment is in accordance with the Danish Confederation of Professional Associations (Akademikerne).
    • Remuneration is in accordance with the above, and the Salary agreement catalogue for staff at Health.
    • The yearly base salary for a fulltime postdoc position with minimum 3 years of working experience after achieved MSc degree is DKK 486,969.17 or DKK 512,713.62 with minimum 4 years of working experience after achieved MSc degree. The base salary includes a position related supplement and pension (17.1 %). Additional supplement(s) for special qualifications can be negotiated. Authorisation supplemement(s) will be granted, if relevant for the position. Your local eligible trade union representative at Aarhus University negotiates your salary on your behalf.
    • Researchers recruited from abroad are offered a special researcher tax scheme with a lower tax rate.
    • Further information on qualification requirements and job description can be found in the.Ministerial Order on Job Structure for Academic Staff

    Application
    Your application must include the following:

    • Motivated application
    • Curriculum Vitae
    • Diploma
    • A list of publications
    • A teaching portfolio. We refer to Guideline on the use of teaching portfolios
    • A maximum of five of the publications of greatest relevance to the job may be submitted
    • Template for applicant - postdoc must be completed and uploaded under ‘Extra documents’
    • Strategic research plan can be uploaded
    • Coauthor statement(s) can be uploaded
    • References/recommendations can be uploaded separately in the e-recruitment system

    We refer to the faculty’s Guidelines for applicants.

    The assessment committee may decide to include non-submitted material in its statement. In such cases, you will be informed and obliged to submit material, unless your application is withdrawn.

    All interested candidates are encouraged to apply, regardless of their personal background.
    Letter of reference
    If you want a referee to upload a letter of reference on your behalf, please state the referee’s contact information when you submit your application. We strongly recommend that you make an agreement with the person in question before you enter the referee’s contact information, and that you ensure that the referee has enough time to write the letter of reference before the application deadline.
    Unfortunately, it is not possible to ensure that letters of reference received after the application deadline will be taken into consideration.
    International applicant?
    Aarhus University offers a broad variety of services for international researchers and accompanying families, including relocation service and career counselling to expat partners. Please find more information about entering and working in Denmark here. Aarhus University also has a Junior Researcher Development Programme. You can read more about it here.

    The application must be submitted via Aarhus University’s recruitment system, which can be accessed under the job advertisement on Aarhus University's website.
    Aarhus University
    Aarhus University is an academically diverse and research-intensive university with a strong commitment to high-quality research and education and the development of society nationally and globally. The university offers an inspiring research and teaching environment to its 38,000 students (FTEs) and 8,000 employees, and has an annual revenues of EUR 885 million. Learn more at www.international.au.dk/

    Application Deadline: 28-02-2021

    Ansøgningsfrist: 28.02.2021

    Placering: Aarhus C Høegh-Guldbergs Gade 10

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    Aarhus Universitet (AU)
    Aarhus Universitet (AU)
    Aarhus Universitet blev grundlagt i 1928 og er i dag i den absolutte verdenselite på flere forskningsfelter. Aarhus Universitet (AU) er blandt verdens 10 bedste universiteter grundlagt inden for de seneste 100 år og har en lang tradition for partnerskaber med nogle af verdens bedste forskningsinstitutioner og universitetsnetværk.

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    Nordre Ringgade 1
    8000 Aarhus C
    Logo: Aarhus Universitet (AU)
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