Specialist in iPSC derived T cell generation and modulation (maternity cover) – DTU Health Tech

If you are a specialist with interest in stem-cell differential and immunology and T cell driven immunotherapies this project employment is a great opportunity. At DTU Health Technology you will work with world leading scientists in the fast-developing field of immunology.
If you are a specialist with interest in stem-cell differential and immunology and T cell driven immunotherapies this project employment is a great opportunity. At DTU Health Tech you will work with world leading scientists in the fast-developing field of immunology.

We are looking for a skilled and experienced specialist who will be responsible for establishing, optimising and using a process/protocol of iPSC-derived T cell maturation. The position is linked to the DigitStem project and is available in the Section of Experimental and Translational Immunology (xTI), DTU Health Tech, at the Technical University of Denmark (DTU).

In the Section of Experimental and Translational Immunology, we are focusing on understanding immune regulation, recognitions and signalling to unravel disease mechanism, and translate immunological finding into therapeutic strategies via design of nanomaterial to actively engage or manipulate the immune system.

The position is part of the DigitStem project, a larger collaboration between Bioneer A/S, Hørsholm, Denmark and DTU, specifically focusing on the development of iPSC derived cell products for clinical use, as cell therapy products for cancer treatment. Novel protocols and screening tools is expected to derive from these projects. The position is specifically linked to the tasks given below.

The job
The present project will be conducted in the research group ‘T cells & Cancer’, under supervision of Professor Sine Reker Hadrup. Responsibilities within the current project:

• Develop protocols for the differentiation of T cells from induced pluripotent stem cells, iPSC
• Explore T cell stimulatory strategies to promote T cell function and optimize the differentiation process
• Generate a pool of allogenic, of-the-shelf T cells, that can be modified with receptors of interest, and test the therapeutic potential of such T cells to standard autologous T cell products, through preclinical models

Today, most cell products are derived from autologous T cell sources, which is a major bottleneck for expanding cell therapy as a sustainable treatment option. Hence, there is an urgent need to develop strategies for off-the-shelf T cell products that can be tailored to patients’ need.

Our expectations of you

• Expertise in Cancer and Immunology, including pre-clinical models T cell therapy and T cell differentiation.
• Hold a PhD, and have additionally 3–4-year research experience

The candidate should be trained in:

• T cell engineering technologies
• Functional evaluation of T cells
• Immunology: T cell recognition, antigen presentation & T cell function
• MHC multimer generation – and T cell staining & analysis
• Analyses of antigen-specific T cells
• Multicolor flow cytometry
• Preclinical cancer models to determine T cell therapy efficacy, in vitro and in vivo
• Apply analytical and statistical tools to identify patterns in large datasets

The candidate should demonstrate evidence of self-driven and technical capabilities, excellent collaboration and communication skills, an interest in working in an interdisciplinary research environment, and a strong motivation to succeed within a competitive research field.

What we offer in return
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The employment is specifically linked to complete the tasks related to maternity leave of a project employee in the DigitStem project, expected to run for 12-14 month.

You can read more about the Department of Health Technology at www.healthtech.dtu.dk/english.

Application and contact
Please submit your online application no later than 21 October 2024 (23:59 Danish time). Open the “Apply now” link, fill out the form and attach your motivated application, CV and exam certificates.

If you would like additional information about the position, please contact Professor Sine Reker Hadrup, [email protected].

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

DTU Health Tech
With a vision to improve health and quality of life through technology, DTU Health Tech engages in research, education, and innovation based on technical and natural science. We educate tomorrow’s health tech engineers and create the foundation for new and innovative services and technologies for the globally expanding healthcare sector with its demands for the most advanced technological solutions. DTU Health Tech’s expertise can be described through five overall research areas: Diagnostic Imaging, Digital Health, Personalised Therapy, Precision Diagnostics, and Sensory and Neural Technology. Our technologies and solutions are developed with the aim of benefiting people and creating value for society. The department has a scientific staff of about 210 persons, 140 PhD Students, and a technical/administrative support staff of about 100 persons of which a large majority contributes to our research infrastructure and related commercial activities.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

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