Expression of interest for a PhD Fellowship in bone fracture nonunion healing by adipose-derived regenerative cells (Odense University Hospital/Univer

BACKGROUND: This is a close collaborative project between Orthopaedic Research laboratory, the Department of Orthopeadic Surgery & Traumatology and Laboratory of Molecular and Cullular Cardiology the department of Clinical Biochemistry, Odense University Hospital (OUH). The project is mainly granted by the Independent Research Fund Denmark (DFF). We seek one PhD fellow to start as soon as possible.

Brief scientific summary: This proposal targets a most challenging orthopaedic problem of fracture nonunion by our already approved adipose-derived regenerative cells (ADRCs) for clinical trials. We establish a possible superior design to current treatments, with least invasive procedures for patients. We harvest adipose tissue from patients through a minimal invasive process. We perform regulatory settings, cell manufacturing and quality controls of ADRCs prior to clinical trials (study 1). We evaluate safety, assess efficacy, and determine optimal dose of ADRCs combined with bone allograft in the treatment of patients with fracture nonunion (study 2). Thereafter, we perform a proof-of-concept clinical trial on the efficacy of ADRCs combined with bone allograft on stimulating fracture atrophic nonunion healing in patients with bone defect (study 3). Thus, provide strong evidence for future large multicenter clinical trials and apply this novel strategy to other types of severe nonunion.

Job content: The candidate will investigate novel mechanisms underlying bone fracture nonunion healing. The candidate focuses on the three parts as described above under supervisions and helps. The candidate will also participate in general management of the lab together with postdoc and other PhDs as well as technician and perform supervision, teaching, and writings (articles/grants/licenses etc.). The employment is planned to ASAP 2025.

Qualifications The qualified applicant holds a master’s degree in Medicine/Cell Biology/Molecular Biology/Biomedicine or similar with experience in research and at least one (either published or expected) authorship in internationally peer-reviewed publications. The candidate is expected to be able to communicate fluently in spoken and written English. For further details please contact Ming Ding, e-mail: .

PRACTICAL INFO:
-Appointment as a PhD Research Fellow is for three years. Employment stops automatically at the end of the period. The holder of the scholarship is not allowed to have other paid employment during the three-year period.
-The successful applicant will be employed in accordance with the agreement of 1 October 2008 on salaried PhD scholars between the Ministry of Finance and AC (the Danish Confederation of Professional Associations).
-The successful candidate will be enrolled at this university in accordance with faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order).
-The university encourages all persons interested in the position to apply, regardless of their age, gender, religious affiliation or ethnic background.
-Application must be made in the form of a Declaration of Interest including the following:

• A letter stating your specific interest, motivation and qualifications for the project in question (max. two pages).
• Detailed CV, including personal contact information.
• Certified copy of diploma including grades. If master degree still awaits-A letter from master main supervisor stating progress of master and expected dissemination should be included.
• At least two references.

Further information about the PhD-study can be found at the homepage of the University

Incomplete applications and applications received after the deadline will neither be considered nor evaluated. This also applies to reference letters.

Application deadlines: 30th April, 2025, kl. 12:00, but applications will be evaluated immediately upon submission until a candidate has been identified.

Afdeling: Ortopædkirurgisk Afdeling O, Odense-Svendborg

Stillingsbetegnelse: Ph.d.- stipendiat, sundhedsvidenskab

Arbejdstid: 37

Arbejdssted: Odense

Application deadline: 30 Apr 2025