Talentprofil #16505 i StuderendeOnline

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Profil #16505

I am competent in scientific support on both process development and manufacturing production. For the last 3+ years, I worked as a downstream scientist in a pharma company (Bavarian Nordic), and thereby I became a downstream and purification expert. I also got a good knowledge and experience on upstream and cell culture.

Downstream Purification Productive Initiative Experienced

Opdateret 11. april 2021

Min uddannelse

2005 - 2009

ph.d. (alm.)

Danmarks Tekniske Universitet - DTU

My PhD study focused on the development of new ways to produce ceramides, which are active components in pharmaceutical and cosmetic industries.

Efficient and scalable methods were developed for the production of ceramide

Expertise on enzyme technology, membrane technology, lipid technology and process development

Experience on experiment design and statistical analysis

• Seven peer reviewed publications on international journals and books.

Uddannelsesområde: Kemi, Biotek & Materialer

Periode: marts 2005 - januar 2009

2002 - 2005

Master

Danmarks Tekniske Universitet - DTU

Master project “Optimization of Enzymatic Modification of Sphingomyelin”
• Broad knowledge and lab experience on Biotechnology, including fermentation, purification, metabolic engineering, molecular biology, and microbiology, etc.

Uddannelsesområde: Kemi, Biotek & Materialer

Periode: september 2002 - marts 2005

1996 - 2000

Bachelor

Anden uddannelsesinstitution i udlandet

Bachelor's degree, Pharmacy Medicine, Shanxi Medical University, China
Bachelor Thesis “The Lithontriptic Effect of Peppermint Extraction”

Broad knowledge and lab experience on pharmacology, organic chemistry, biochemistry, GMP, physiology, and pathology, etc.

• One peer reviewed article regarding the Bachelor thesis was published in a journal.

Uddannelsesområde: Medicinal & Sundhed

Periode: september 1996 - juli 2000

Min erhvervserfaring

2013 - 2017

Downstream scientist

Bavarian Nordic A/S

Bavarian Nordic is a pharmaceutical company focused on the development, manufacturing and commercialization of cancer immunotherapies and vaccines for infectious diseases. I worked in Process Development department, which plays a crucial role on process investigation, new process development, process validation for new products, and support on manufacturing production.

I worked primarily as a downstream scientist and also have a good knowledge and experience on upstream processes in cell culture.

Investigation and optimization of downstream and upstream process at pilot scale

Developing new processes, e.g. new TFF process, to replace the current process in production

Production process design for new products.

Scientific support on process validation for new products, including DoE study, CPP evaluation, reviewing validation report, support on engineering runs, etc.

Process upscaling from pilot to production scale. Support and training for newly implemented process at production.

Tech transfer between different sites in the company and between CMO and the company.

Process support and troubleshooting on manufacturing production, e.g. help on deviations, OOS and change control from GMP batches.

Preparation, draft review and record review of Master Batch Journal for the production of preclinical material at pilot scale.

Selection and qualification of equipment at pilot plant, e.g. TFF, Sonicator, pump, etc. Help on qualification of equipment in manufacturing.

Analysis method setup and validation in PD, e.g. SDS-PAGE, BCA, UV280, viscosity, density, DNA gel.

Close collaboration with different departments, e.g. R&D, Production, QC, QA, PM, etc.

I got thorough training on cGMP and documentation. I practiced them every day.

Our group applied LEAN in the daily work, and used several whiteboards for planning the tasks, organizing staff training, and KPI, etc.

• Writing and reviewing study plans, protocols, SOP, reports and deviations.

Arbejdsområde: Produktion

Periode: juni 2013 - januar 2017

2012 - 2013

Post doc

Copenhagen University

• Developing lipid formulation to improve oral drug delivery system
• Developing lipid quantification methods (GC, HPTLC, HPLC)
• In vitro lipolysis (Simulation of intestinal environment)
• Two peer reviewed articles were published in international journals

Arbejdsområde: Forskning & Udvikling

Periode: juni 2012 - april 2013

2010 - 2011

Post doc

Technical University of Denmark

I joined in a project, “Enzymatic production of human milk oligosaccharides”
• Protein purification process development (Affinity chromatography, Size exclusion chromatography)
• Enzyme (sialyl-transferase) assays development by fluorescent and absorbance
• Protein characterization (SDS-PAGE, BCA, Silver staining, Western blot, etc.)

Arbejdsområde: Forskning & Udvikling

Periode: april 2010 - april 2011

Mine kompetencer

Evner

affinity and size exclusion chromatography cell lysis centrifugation depth filtration diafiltration dna degradation doe design downstream holding time study impurity clearance liquid-liquid and liquid-particle mixing pilot production problem solving process development root cause investigation sonication str incubation tech transfer ultracentrifugation upscaling upstream viafuge viscosity microfiltration process investigation process support and training roller bottle tangential flow filtration ultrafiltration validation wave bag

Sprog på arbejdsniveau

dansk (midt niveau) engelsk kinesisk

Mine præferencer

Jobtype

Fuldtidsjob Vikariat

Arbejdsområde

Forskning & Udvikling Produktion

Geografi

Bornholm Fyn Grønland & Færøerne Midtjylland Nordjylland Nordsjælland Storkøbenhavn Sydsjælland & Øer Sydvestjylland (Esbjerg) Sydøstjylland Sønderjylland Udlandet (Norge) Udlandet (Sverige) Udlandet (øvrige) Vestjylland Vestsjælland Øresundsregionen Østjylland (Aarhus) Østsjælland

Læs mere / links

https://www.linkedin.com/in/lo...