Postdoc in Developing Nanoparticle-Based Drug Delivery System for in vivo Protein/Gene Delivery - DTU Health Tech

Center for Nano-Immune Cell-Engineering (NICE) at the Department of Health Technology (DTU Health Tech) invites a highly motivated Postdoctoral Researcher to join our group in developing advanced polymeric nanoparticle systems for in vivo protein/gene delivery.

The project focuses on engineering and characterizing stimuli-responsive nanocarriers for targeted, safe, and efficient delivery of biomacromolecules, such as CRISPR–Cas9 protein complexes, therapeutic enzymes, and other biomolecule-based drugs. This position is ideal for candidates with strong interests in nanomedicine, biomaterials, drug delivery, and translational biotechnology.

We provide

• Access to state-of-the-art research facilities and fabrication labs
• A vibrant, collaborative, and inclusive research environment
• Opportunities to mentor students and collaborate with academic and industrial partners
• A chance to contribute to impactful research in personalized healthcare

The overarching goal is to build smart nanoparticle platforms that enable precise control over cargo loading, stability, release kinetics, and functional activity in tumor models.

Responsibilities:

• Design, synthesize, and characterize polymeric nanoparticles, including degradable polymers, block copolymers, and responsive materials.
• Develop protein/gene delivery formulations, including Cas9 RNPs, therapeutic enzymes, or antibody fragments.
• Engineer stimuli-responsive release mechanisms (e.g., pH, enzymatic).
• Collaborate with interdisciplinary team members (e.g. immunologists, molecular biologists) to conduct in vitro assays to evaluate protein activity and cellular interaction, and perform in vivo biodistribution and therapeutic efficacy studies in animal models.
• Publish high-impact manuscripts and present research at international conferences.

Qualifications:

• As a formal qualification, you must hold a PhD degree (or equivalent) in Biomedical Engineering, Chemical Engineering, Materials Science, Pharmacy, Nanomedicine, or a related field.
• Experience in protein/gene formulation, biomolecule handling, or macromolecular complexes.
• Knowledge of stimuli-responsive materials (pH-, enzyme-responsive systems).
• Strong skills in nanoparticle synthesis for protein/gene delivery (polymeric, lipid, or hybrid systems).
• Experience with nanoparticle physicochemical characterization (DLS, TEM, NMR, SEC, zeta potential).
• Background in in vivo drug delivery, or pharmacokinetic studies.
• Familiarity with microfluidic nanoparticle formulation or polymer chemistry.
• Excellent communication and scientific writing skills.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

The period of employment is 1 year, and will start as soon as possible.

The position will be based at the DTU Lyngby Campus, Denmark,

You can read more about career paths at DTU here.

Further information
Further information may be obtained from Professor Yi Sun ([email protected]).

You can read more about DTU Health Tech at www.healthtech.dtu.dk.

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.

Application procedure
Your complete online application must be submitted no later than 10 February 2026 (23:59 Danish time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

• Application (cover letter)
• CV
• Academic Diplomas (MSc/PhD – in English)
• List of publications
• Contact information for 2–3 references

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. As DTU works with research in critical technology, which is subject to special rules for security and export control, open-source background checks may be conducted on qualified candidates for the position.

DTU Health Tech
DTU Health Tech engages in research, education, and innovation base on technical and natural science for the healthcare sector. The Healthcare sector is a globally expanding market with demands for the most advanced technological solutions. DTU Health Tech creates the foundation for companies to develop new and innovative services and products which benefit people and create value for society. DTU Health Techs expertise spans from imaging and biosensor techniques, across digital health and biological modelling, to biopharma technologies. The department has a scientific staff of about 210 persons, 130 PhD students and a technical/administrative support staff of about 160 persons, of which a large majority contributes to our research infrastructure and related commercial activities.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

Location
Kgs. Lyngby, Denmark

Apply Before
2026-02-10T22:59:00+00:00